|
KMID : 0383119750230010031
|
|
Journal of Aerospace Medicine
1975 Volume.23 No. 1 p.31 ~ p.38
|
|
|
The Effect of Vitamin E and Ginseng Extract on Pulmonary Oxygen Toxicity
|
|
|
|
|
Abstract
|
|
|
Pulmonary oxygen toxicity, characterized by severe atelectasis, hyaline membrane formation and edema in man and various animals, is one of very important complications in clinical application of hyperbaric medicine, but the exact mechanism of this toxic effect is not clarified yet.
This study was undertaken to investigate the characteristics of the pulmonary lesions in rats induced under hyperbaric pure oxygen environment and the effect of vitamin E, one of the well known anti-oxidant, and ginseng extract, which might have an effect of nonspecific stress reduction.
Eighty female rats were used and exposed to oxygen at 2 atm. pressure in hyperbaric pressure chamber for 18 and 28hours. In vitamin E pretreated group, Tofaxin. (DL-α-Tocopherol) was injected intramuscularly with daily dose of 10mg per 100gm body weight for 2 weeks prior to exposure. In ginseng pretreated group, methanol extract was given orally with the daily dose of 5mg per 100gm of body weight for 2 weeks prior to exposure.
The characteristic pulmonary congestion and interstitial edema were found at 1a hours after exposure, but hyaline membrane formation and atelectasis were not characteristic findings in rat.
Vitamin E seems to have protective effect on pulmonary oxygen toxicity but ginseng extract had no effect in preventing this toxicity.
Adrenal glands showed neither histopathological nor weight changes by hyperbaric oxygen.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|